Effects of Peripheral Arterial Disease on Outcomes in Advanced Chronic Systolic Heart Failure
Key result
Peripheral arterial disease in advanced chronic systolic heart failure was associated with increased all-cause mortality compared to no PAD (43% vs 33%; HR 1.40; 95% CI 1.14-1.72; P=0.001).
Why the study?
Does a history of peripheral arterial disease increase mortality and hospitalization in patients with advanced chronic systolic heart failure?
Population
2689 patients with advanced chronic systolic heart failure from the Beta-Blocker Evaluation of Survival…
Comparison
History of peripheral arterial disease (PAD) vs No history of peripheral arterial disease (PAD)
Design
Cohort
Follow-up
4.1 years
Authors
Discussion
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Member takes
Implication
PAD signals higher mortality risk in advanced systolic HF; extends observational data but leaves open interventional implications.
Study Design
Type
Cohort (n=1,314)
Structured PICO
Does a history of peripheral arterial disease increase mortality and hospitalization in patients with advanced chronic systolic heart failure?
P
Population
1,314 propensity-matched patients with advanced chronic systolic heart failure, with and without a history of peripheral arterial disease, followed for 4.1 years.
E
Exposure
History of peripheral arterial disease (PAD)
C
Comparator
No history of peripheral arterial disease (PAD)
O
Outcome
All-cause mortality and all-cause hospitalizationhard clinical
Main Result
Hazard Ratio: 1.4 (95% CI 1.14–1.72)
Absolute Event Rate: 43% vs 33%
p-value: p=0.001
In patients with advanced chronic systolic heart failure, a history of peripheral arterial disease is independently associated with significantly increased risks of all-cause mortality and hospitalization.
Cite This Study
Ahmed et al. (2009) conducted a cohort in advanced chronic systolic heart failure (n=1,314). Peripheral arterial disease vs. No history of peripheral arterial disease was evaluated on All-cause mortality (HR 1.40, 95% CI 1.14-1.72, p=0.001). Peripheral arterial disease in advanced chronic systolic heart failure was associated with increased all-cause mortality compared to no PAD (43% vs 33%; HR 1.40; 95% CI 1.14-1.72; P=0.001).