Key result
In atrial fibrillation patients, peripheral artery disease was associated with higher crude MACE rates (6.99%/year vs 3.18%/year, P<0.01), but not after multivariable adjustment.
Why the study?
AF and PAD are common conditions that increase cardiovascular risk, but the association between PAD and prognosis in real-world patients receiving oral anticoagulant therapy for nonvalvular AF required determination.
Does the presence of peripheral artery disease increase the risk of adverse clinical outcomes in patients with nonvalvular atrial fibrillation receiving oral anticoagulation?
Population
1956 patients receiving oral anticoagulant therapy for AF
Comparison
Patients with PAD vs without PAD
Design
Prospective registry cohort study
Follow-up
3 years
Authors
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No independent association after adjustment in anticoagulated AF; leaves open incremental prognostic value beyond standard risk factors.
Cohort (n=1,956)
Does the presence of peripheral artery disease increase the risk of adverse clinical outcomes in patients with nonvalvular atrial fibrillation receiving oral anticoagulation?
Absolute Event Rate: 6.99% vs 3.18%
p-value: p=<.01
In anticoagulated patients with atrial fibrillation, peripheral artery disease is a marker of higher crude cardiovascular risk but is not independently associated with adverse outcomes after adjusting for other risk factors.
Bertomeu‐González et al. (2020) conducted a cohort in Nonvalvular atrial fibrillation (n=1,956). Peripheral artery disease (PAD) vs. No peripheral artery disease was evaluated on Major adverse cardiovascular events (MACE) (p=<.01). In atrial fibrillation patients, peripheral artery disease was associated with higher crude MACE rates (6.99%/year vs 3.18%/year, P<0.01), but not after multivariable adjustment.
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