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December 9, 2016EP EuropaceOpen Access

PAD was associated with a higher risk of all-cause death on Kaplan-Meier analysis (P < 0.0001), but did not emerge as an independent risk factor for mortality on Cox regression analysis after adjustment.

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Why the study?

Does the presence of peripheral arterial disease increase the risk of all-cause death in patients with atrial fibrillation?

Population

European atrial fibrillation patients enrolled in the EORP-AF Pilot study with data about peripheral…

Comparison

Presence of symptomatic peripheral arterial… vs Absence of peripheral arterial disease (PAD)

Design

Cohort

Follow-up

1-year

Authors

MPMarco ProiettiVRValeria RaparelliCLCécile Laroche

Discussion

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Overview

PAD not independent mortality predictor in AF after adjustment; leaves open confounding by prevention therapies in observational cohorts.

Structured PICO

Does the presence of peripheral arterial disease increase the risk of all-cause death in patients with atrial fibrillation?

P
Population
European atrial fibrillation patients enrolled in the EORP-AF Pilot study with data about peripheral arterial disease (PAD) status.
I
Intervention
Presence of symptomatic peripheral arterial disease (PAD)
C
Comparator
Absence of peripheral arterial disease (PAD)
O
Outcome
All-cause death at 1-year follow-uphard clinical

In patients with atrial fibrillation, peripheral arterial disease is not an independent risk factor for all-cause mortality after adjusting for the use of cardiovascular prevention drugs.

Cite This Study

Proietti et al. (2016) studied this question.

synapsesocial.com/papers/6a812a791c90fa4c6da8cfdfhttps://doi.org/10.1093/europace/euw169
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Peripheral artery disease and clinical outcomes in patients with atrial fibrillation: A report from the FANTASIIA registry2020 · 6 citations
  2. 2Peripheral artery disease and clinical outcomes in patients with atrial fibrillation: A systematic review and meta‐analysis2021 · 11 citations
  3. 3Peripheral artery disease, antithrombotic treatment and outcomes in European and Asian patients with atrial fibrillation: analysis from two prospective observational registries2024 · 25 citations
  4. 4Atrial fibrillation and risk of cardiovascular events and mortality in patients with symptomatic peripheral artery disease: A meta‐analysis of prospective studies2017 · 35 citations
  5. 5Vascular disease in patients with atrial fibrillation. A report from Polish participants in the EORP‐AF General Long‐Term Registry2020 · 4 citations