1586 Objectives: We aimed to study the spontaneous change in liver FDG uptake over a longertime period of 2 years as this is the background upon which pathologic change in liver FDG accumulation must be interpreted. Methods: This study was done as a follow up to the previous study known as CAMONA in Odense, Denmark. Out of 89 healthy subjects who underwent a baseline FDG-PET/CT scan approximately 180 minutes following tracer administration, 29 healthy subjects (19 males, 10 females) underwent a secondary FDG-PET/CT scan after two years. In between none of the patients had suffered from serious illness and none of them had received medication other than pain killers and vitamins. We obtained Global SUVmean and SUVmax at both time points in the same manner by putting regions of interests within the anatomical borders of the entire liver using OsiriX MD software (Pixmeo SARL, Bernex, Switzerland). We used a paired t-test to assess the significance of changes in uptake. Results: Among the 29 healthy subjects, 20 had an increase and 9 had a decrease in SUVmean, whereas 16 subjects had an increase and 13 had a decrease in SUVmax. The average SUVmean at baseline and follow up were 1.52 and 1.58, respectively, (p=0.10). The corresponding average SUVmax values were 3.23 and 3.07, respectively, (p=0.06).Conclusion: According to our results, FDG uptake in the liver in healthy subjects does not significantly change after two years. This suggests that significant changes in liver FDG uptake over this time interval could indicate an underlying dysfunction.
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Xu et al. (2002) studied this question.