Mucoepidermoid Carcinoma of the Breast

Following surgery, the pathologist reported a grade 3 large-cell neuroendocrine tumor.Four of 11 nodes were involved; vascular invasion was present and the posterior resection margin was close to the edge of the tumor although it was completely excised.Immunohistochemistry showed the tumor to be estrogen and progestogen receptor positive, but HER2 negative with a Nottingham Prognostic Index of 6.24.At postoperative clinical review, the patient was offered chemotherapy (carboplatin and etoposide), these being the first line treatment for neuroendocrine tumors whether of the breast or elsewhere.