Key result
Tenosynovial biopsy during carpal tunnel release identifies TTR amyloid deposits in ~34% of patients.
Why the study?
Wild-type transthyretin cardiac amyloidosis is a life-threatening progressive disease and the role of detecting transthyretin amyloid in tenosynovial tissue for diagnosis is important but not fully clarified.
What is the prevalence of TTR amyloid deposits in Japanese patients undergoing carpal tunnel release, and what is the clinical significance of concomitant 99mTc-PYP scintigraphy?
Observational (n=79)
No
What is the prevalence of TTR amyloid deposits in Japanese patients undergoing carpal tunnel release, and what is the clinical significance of concomitant 99mTc-PYP scintigraphy?
This study aims to evaluate the prevalence of tenosynovial TTR amyloidosis and the utility of 99mTc-PYP scintigraphy for early detection of cardiac amyloidosis in patients undergoing carpal tunnel release.
Answers are grounded in this paper and cite their sources.
May support targeted ATTRwt-CA screening in Japanese carpal tunnel patients; leaves open prospective validation of 99mTc-PYP utility.
Background:Wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) is a life-threatening progressive disease. Recent studies have shown that the detection of transthyretin (TTR) amyloid in tenosynovial tissue may play an important role in the diagnosis of cardiac amyloidosis. The aim of this study was to determine the prevalence of TTR amyloid deposits in surgical tissue of patients undergoing carpal tunnel surgery and to clarify the clinical significance of concomitant cardiac examination with 99 mTc-labeled pyrophosphate (99 mTc-PYP) scintigraphy in those patients with TTR deposition.
No takes yet. Share an insight, caveat, or question.
Sugiura et al. (2021) conducted an observational in Carpal tunnel syndrome (n=79). Tenosynovial tissue biopsy and 99mTc-PYP scintigraphy was evaluated on Prevalence of TTR amyloid deposition in tenosynovial tissue. TTR amyloid deposition in tenosynovial tissue was observed in 34% of Japanese patients undergoing carpal tunnel release, and concomitant 99mTc-PYP scintigraphy identified ATTRwt-CA in 19% of those tested.
Synapse has enriched 10 related papers. Consider them for comparative context: