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Four new cytotoxic kabiramides (1-4) together with the known kabiramides B, C, and D have been isolated from the sponge Pachastrissa nux collected in the Gulf of Thailand.The structures of the new entities were elucidated by spectroscopic methods.Kabiramide C derivatives (8-11) were prepared and evaluated for cytotoxicity together with the natural congeners.
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Tanaka et al. (2006) studied this question.
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