Shared burden of ultra-rare genetic variants across a spectrum of motor neuron diseases

This is the authors' abstract. We don't add key points for this paper.

Emerging evidence suggests an intricate genetic architecture in motor neuron diseases (MNDs), involving not only monogenic causes but also, to varying extents, risk alleles and oligogenic or polygenic contributions [1-3].The potential for shared genetic risk across related diseases has motivated us to examine the contributions of rare variants in canonical and non-canonical diseaseassociated genes in a group of MNDs to understand the † Gang Wu and Michael Benatar contributed equally.