What question did this study set out to answer?

To assess the safety, clinical efficacy, and dose-volume histogram metrics of carbon-ion radiotherapy compared to photon therapy in patients with T2b-4N0M0 non-small cell lung cancer.

April 11, 2017PLoS ONEOpen Access

Clinical outcomes using carbon-ion radiotherapy and dose-volume histogram comparison between carbon-ion radiotherapy and photon therapy for T2b-4N0M0 non-small cell lung cancer—A pilot study

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Authors

KSKatsuyuki ShiraiJichi Medical University MKMotohiro KawashimaGunma University JSJun-ichi SaitohGunma University

Discussion

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Implication

Pilot study reveals high local control and reduced lung irradiation with carbon-ion radiotherapy in T2b-4N0M0 lung cancer, suggesting superior dosimetric sparing over photon therapy.

Key Points

To assess the safety, clinical efficacy, and dose-volume histogram metrics of carbon-ion radiotherapy compared to photon therapy in patients with T2b-4N0M0 non-small cell lung cancer.
Evaluated 23 patients (median age 78 years, range 53–91; 11 operable, 12 inoperable) treated with carbon-ion radiotherapy between May 2011 and December 2015, with a median follow-up of 25 months.
Delivered carbon-ion radiotherapy regimens of 60.0 Gy (relative biological effectiveness [RBE]) in 4 fractions or 64.0 Gy (RBE) in 16 fractions in 91% of patients.
Compared normal lung dose-volume histogram parameters and tumor target coverage between carbon-ion radiotherapy, three-dimensional conformal radiotherapy, and intensity-modulated radiotherapy.
The 2-year local control rate was 81% (3 patients developed local recurrence), and the 2-year overall survival rate was 70%.
Operable patients demonstrated a significantly higher overall survival rate than inoperable patients (100% vs. 43%; P = 0.04).
Carbon-ion radiotherapy delivered a significantly lower radiation dose to normal lung tissue and superior tumor coverage compared with photon therapies, with zero cases of grade ≥2 radiation pneumonitis.

Cite This Study

Shirai et al. (2017) studied this question.

synapsesocial.com/papers/6ab62859126f8a2742dc1abc https://doi.org/10.1371/journal.pone.0175589

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Implication

Pilot study reveals high local control and reduced lung irradiation with carbon-ion radiotherapy in T2b-4N0M0 lung cancer, suggesting superior dosimetric sparing over photon therapy.

Clinical outcomes using carbon-ion radiotherapy and dose-volume histogram comparison between carbon-ion radiotherapy and photon therapy for T2b-4N0M0 non-small cell lung cancer—A pilot study

Discussion

Member takes

Implication

Key Points

Cite This Study

Clinical outcomes using carbon-ion radiotherapy and dose-volume histogram comparison between carbon-ion radiotherapy and photon therapy for T2b-4N0M0 non-small cell lung cancer—A pilot study

Discussion

Member takes

Implication

Key Points

Cite This Study

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