Key result
Electroconvulsive therapy significantly decreased plasma noradrenaline in patients with melancholic or psychotic depression, with a trend associating this fall with clinical improvement.
Why the study?
Does electroconvulsive therapy alter plasma noradrenaline levels in patients with depressive illness?
Population
Patients referred for ECT who suffered from DSM-III-R major depressive disorder or dysthymia
Design
Cohort
Follow-up
weekly during the course of ECT
Authors
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ECT-linked noradrenaline shifts differ by depression subtype and may track improvement; leaves open predictive value for future trials.
Observational
Does electroconvulsive therapy alter plasma noradrenaline levels in patients with depressive illness?
ECT decreases plasma noradrenaline in melancholic/psychotic depressive illness, which shows a trend associated with clinical improvement.
Kelly et al. (1997) conducted an observational in DSM-III-R major depressive disorder or dysthymia. Electroconvulsive therapy was evaluated on Change in resting plasma noradrenaline. Electroconvulsive therapy significantly decreased plasma noradrenaline in patients with melancholic or psychotic depression, with a trend associating this fall with clinical improvement.
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