Key result
Statin therapy linked to ~98% lower MI risk vs the pre-statin period.
Why the study?
The impact of statin therapy on long-term cardiovascular outcomes in an outpatient cardiology practice was evaluated to understand its effect on MI, PCI, and CABGS incidence.
Does statin therapy reduce the incidence of MI, PCI, and CABGS in patients in an outpatient cardiology practice?
Cohort (n=305)
No
Does statin therapy reduce the incidence of MI, PCI, and CABGS in patients in an outpatient cardiology practice?
Statin therapy in an outpatient cardiology practice significantly reduces the long-term incidence of MI, PCI, and CABGS.
Answers are grounded in this paper and cite their sources.
Statin use was associated with fewer MIs in outpatients; hypothesis-generating and requires randomized confirmation.
BACKGROUND: Statins reduce coronary events in patients with coronary artery disease. MATERIAL/METHODS: Chart reviews were performed in 305 patients (217 men and 88 women, mean age 74 years) not treated with statins during the first year of being seen in an outpatient cardiology practice but subsequently treated with statins. Based on the starting date of statins use, the long-term outcomes of myocardial infarction (MI), percutaneous coronary intervention (PCI), and coronary artery bypass graft surgery (CABGS) before and after statin use were compared. RESULTS: Mean follow-up was 65 months before statins use and 66 months after statins use. MI occurred in 31 of 305 patients (10%) before statins, and in 13 of 305 patients (4%) after statins (p < 0.01). PCI had been performed in 66 of 305 patients (22%) before statins and was performed in 41 of 305 patients (13%) after statins (p < 0.01). CABGS had been performed in 56 of 305 patients (18%) before statins and was performed in 20 of 305 patients (7%) after statins (p < 0.001). Stepwise logistic regression showed statins use was an independent risk factor for MI (odds ratio = 0.0207, 95% CI, 0.0082-0.0522, p < 0.0001), PCI (odds ratio = 0.0109, 95% CI, 0.0038-0.0315, p < 0.0001), and CABGS (odds ratio = 0.0177, 95% CI = 0.0072-0.0431, p<0.0001.) CONCLUSIONS: Statins use in an outpatient cardiology practice reduces the incidence of MI, PCI, and CABGS.
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Lai et al. (2011) conducted a cohort in Coronary artery disease (n=305). Statin therapy vs. Period before statin use was evaluated on Myocardial infarction (MI) (OR 0.0207, 95% CI 0.0082-0.0522, p=<0.0001). Statin therapy significantly reduced the incidence of myocardial infarction compared to the period before statin use (4% vs 10%; OR 0.0207, 95% CI 0.0082-0.0522, p<0.0001).
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