A case of constrictive pericarditis after COVID-19 vaccine

It is known that mRNA vaccines against COVID-19 infection are effective in reducing symptoms, mortality and hospitalization of the patients suffering from COVID-19. In fact, these can cause some complications, as fever, headache, dizziness and, rarely, can induce some cardiac involvement, such as the inflammatory reaction of myocardium and/or pericardium. We describe a case of young healthy male-subject who received a second dose of Spikevax vaccine. Two days from the vaccine inoculation, he developed an acute inflammation of the pericardial leaflets, responsible for constrictive pericarditis. The clinical suspect was confirmed by instrumental and laboratory data. But, after the anti-inflammatory drugs administration, he completely recovered. Learning objective: This case report describes the occurrence of constrictive pericarditis following the vaccination against COVID-19. The most common instrumental and laboratory texts, useful for the diagnosis, are illustrate. The therapeutic treatment are reported. The pathogenetic mechanisms are hypothesized.