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All articles of this category The enantioselective Pictet-Spengler reaction catalyzed by chiral binaphthol-derived Brønsted acid-assisted Lewis acids is demonstrated. The Pictet-Spengler reaction of nitrones, prepared from N b -hydroxytryptamine with aldehydes, gave the corresponding 1-substituted-2-hydroxytetrahydro-β-carbolines with up to 91% ee. enantioselective Pictet-Spengler reaction - nitrones - β-carbolines - chiral Brønsted acid-assisted Lewis acids
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Kawate et al. (1997) studied this question.
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