Key result
Serum levels of ANGPTL-4, ASGP-R1, S100A8, hyaluronic acid, and collagen IV were significantly elevated in patients with alcoholic liver cirrhosis compared to healthy controls and increased with disease progression.
Case-Control (n=94)
No
p-value: p=0.007
Serum levels of ANGPTL-4, ASGP-R1, S100A8, hyaluronic acid, and collagen IV are elevated in alcoholic liver cirrhosis and correlate with disease severity, suggesting potential diagnostic and prognostic utility.
Biomarker elevations may indicate alcoholic cirrhosis severity; hypothesis-generating and should not yet change practice.
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Prystupa et al. (2020) conducted a case-control in Alcoholic liver cirrhosis (n=94). Alcoholic liver cirrhosis vs. Healthy subjects without a history of alcohol abuse was evaluated on Serum ANGPTL-4 levels (p=0.007). Serum levels of ANGPTL-4, ASGP-R1, S100A8, hyaluronic acid, and collagen IV were significantly elevated in patients with alcoholic liver cirrhosis compared to healthy controls and increased with disease progression.
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