Key result
Regular aspirin use is linked to ~146% higher risk of neovascular AMD vs nonuse.
Why the study?
The association between regular aspirin use and the risk of developing age-related macular degeneration was uncertain.
Does regular aspirin use increase the risk of developing age-related macular degeneration in a general population cohort?
Cohort (n=2,389)
Does regular aspirin use increase the risk of developing age-related macular degeneration in a general population cohort?
Odds Ratio: 2.46 (95% CI 1.25–4.83)
Absolute Event Rate: 9.3% vs 3.7%
Regular aspirin use over a 15-year period is associated with a significantly increased risk of developing neovascular (wet) age-related macular degeneration, independent of cardiovascular disease history.
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Regular aspirin use was associated with neovascular AMD risk in this cohort; leaves open causality and whether findings should alter prescribing.
Liew et al. (2013) conducted a cohort in Age-related macular degeneration (AMD) (n=2,389). Regular aspirin use vs. Nonusers was evaluated on Incident neovascular (wet) AMD (OR 2.46, 95% CI 1.25-4.83). Regular aspirin use was associated with an increased risk of incident neovascular age-related macular degeneration compared to nonuse (9.3% vs 3.7%; OR 2.46, 95% CI 1.25-4.83).
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