Key result
A3F RNPs display greater resistance to RNase digestion and lack Ro60 and La autoantigens as well as small polymerase III RNAs compared to A3G RNPs, though both contain Alu RNA.
Identifies subtle differences in the protein and RNA compositions of A3F and A3G RNPs, which may explain their functional differences.
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A3F mirrors A3G in RNP associations; extends comparative antiviral analyses but leaves open functional or therapeutic implications.
Gallois‐Montbrun et al. (2008) studied this question. APOBEC3F and APOBEC3G was evaluated on Protein and RNA compositions of A3F- and A3G-associated ribonucleoprotein complexes. A3F RNPs display greater resistance to RNase digestion and lack Ro60 and La autoantigens as well as small polymerase III RNAs compared to A3G RNPs, though both contain Alu RNA.
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