Key result
Distal mean nocturnal baseline impedance accurately distinguished abnormal acid exposure time phenotypes from normal phenotypes with an AUROC of 0.857.
Why the study?
Does distal mean nocturnal baseline impedance (MNBI) differentiate between GERD phenotypes in patients undergoing MII/pH?
Observational (n=62)
No
Does distal mean nocturnal baseline impedance (MNBI) differentiate between GERD phenotypes in patients undergoing MII/pH?
Effect estimate: AUROC 0.857 (95% CI 0.762-0.952)
p-value: p=<0.001
Distal mean nocturnal baseline impedance is a useful metric for differentiating GERD phenotypes, particularly in distinguishing abnormal from normal acid exposure time and separating functional heartburn from reflux hypersensitivity.
Distal MNBI may aid GERD phenotyping on pH-impedance; hypothesis-generating and requires prospective validation before practice change.
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Sararu et al. (2023) conducted an observational in Gastroesophageal reflux disease (GERD) phenotypes (n=62). Distal mean nocturnal baseline impedance (MNBI) vs. Proximal MNBI was evaluated on Diagnostic accuracy in distinguishing abnormal acid exposure time phenotypes (ERD, NERD) from normal phenotypes (RH, FH) (AUROC 0.857, 95% CI 0.762-0.952, p=<0.001). Distal mean nocturnal baseline impedance accurately distinguished abnormal acid exposure time phenotypes from normal phenotypes with an AUROC of 0.857.
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