Key result
Drag-reducing polymer injections substantially reduce aortic and coronary plaque in hypercholesterolemic preclinical models.
Why the study?
Initiation of arterial plaque formation may be influenced by fluid-mechanical factors such as turbulence and boundary layer dynamics, which drag reducing polymers could alter.
Does drag reducing polymer injection reduce arterial plaque accumulation in White Carneau pigeons on high cholesterol diets?
Population
White Carneau pigeons on high cholesterol diets
Comparison
Periodic injections with drag reducing polymer vs control birds
Design
Preclinical pilot studies
Authors
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Should not yet inform clinical practice; leaves open whether drag-reducing polymers alter atherosclerosis in humans.
Does drag reducing polymer injection reduce arterial plaque accumulation in White Carneau pigeons on high cholesterol diets?
Drag reducing polymers may reduce arterial plaque accumulation by altering fluid-mechanical phenomena in a pigeon model of atherosclerosis.
Greene et al. (1980) studied Atherosclerosis. Drag reducing polymer (Separan AP-30) vs. Control birds was evaluated on Arterial plaque accumulations in aortas and coronary arteries. Periodic injection of a drag reducing polymer (Separan AP-30) substantially reduced arterial plaque accumulations in the aortas and coronary arteries of pigeons on high cholesterol diets.
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