Key result
Incomplete surgical resection is linked to a ~10-fold higher risk of postoperative VTE.
Why the study?
Clinical risk factors for venous thromboembolism in postoperative lung cancer patients were not well defined to guide prevention and treatment.
What are the clinical risk factors for venous thromboembolism in postoperative lung cancer patients?
Population
1,001 postoperative lung cancer patients with confirmed surgical pathology diagnosis and complete clinical and follow-up records
Comparison
Patients with incomplete resection, anti-angiogenesis treatment, EGFR-TKI treatment, or increased D-dimer level versus those without these factors
Design
Retrospective cohort study
Follow-up
Median 25.73 ± 0.11 months
Authors
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Warrants caution in high-risk patients after cancer surgery; leaves open whether targeted prophylaxis reduces VTE.
Cohort (n=1,001)
What are the clinical risk factors for venous thromboembolism in postoperative lung cancer patients?
Hazard Ratio: 9.867 (95% CI 5.275–18.459)
p-value: p=0.000
Incomplete surgical resection, anti-angiogenesis drugs, EGFR-TKI use, and elevated preoperative D-dimer are significant risk factors for VTE in postoperative lung cancer patients.
Yang et al. (2012) conducted a cohort in Lung cancer (n=1,001). Incomplete surgical resection vs. Complete surgical resection was evaluated on Venous thromboembolism (VTE) (HR 9.867, 95% CI 5.275-18.459, p=0.000). Incomplete surgical resection (HR 9.867), anti-angiogenesis treatment (HR 3.472), EGFR-TKI treatment (HR 2.808), and increased D-dimer (HR 7.520) were significant risk factors for postoperative VTE.
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