Break on through: High-resolution multidimensional solid-state NMR spectroscopy was used to refine the molecular conformation of a seven-helical transmembrane photoreceptor in lipids (see picture, right). H/D exchange experiments (see picture, left; black spectrum: H2O, red spectrum: D2O) reveal the solvent-exposed surface of the protein, which is asymmetrically positioned in the bilayer.
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Shi et al. (2010) studied this question.