Key result
Depression in post-myocardial infarction patients was associated with significantly higher serum AA/EPA ratios compared to non-depressed patients, with no significant difference in CRP levels.
Why the study?
Lower levels of n-3 LCPUFAs and increased inflammation have been associated with both depressive disorder and myocardial infarction, but their relationship in depressed post-MI patients was unclear.
Does depression post-MI associate with higher AA/EPA ratios and increased CRP levels compared to non-depressed post-MI patients?
Observational (n=50)
Does depression post-MI associate with higher AA/EPA ratios and increased CRP levels compared to non-depressed post-MI patients?
Depressed post-MI patients exhibit altered omega-3 polyunsaturated fatty acid status, specifically higher AA/EPA ratios, without increased systemic inflammation as measured by CRP.
Elevated AA/EPA ratios associate with post-MI depression without CRP differences; hypothesis-generating for omega-3 supplementation, requiring prospective trials before practice change.
OBJECTIVE: Lower levels of long-chain omega-3 polyunsaturated fatty acids (n-3 LCPUFAs) and increased inflammation have been associated with both depressive disorder and myocardial infarction (MI). The present study investigated whether patients who develop depression post-MI, have higher arachidonic acid/eicosapentanoic acid (AA/EPA) ratios than non-depressed post-MI patients and whether depressed post-MI patients have signs of increased inflammation as measured by C-reactive protein (CRP). METHOD: Serum AA/EPA ratio and plasma CRP levels were quantified in 50 post-MI patients, of which 29 were depressed and 21 non-depressed. RESULTS: Compared with the non-depressed group, depressed post-MI patients had significantly higher AA/EPA ratios. No significant difference was observed in CRP levels. CONCLUSION: Depressed post-MI patients had lower levels of n-3 LCPUFAs as measured by mean AA/EPA ratio and no signs of increased inflammation as determined by CRP levels.
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Schins et al. (2006) conducted an observational in Post-myocardial infarction with or without depression (n=50). Depression vs. No depression was evaluated on Serum AA/EPA ratio and plasma CRP levels. Depression in post-myocardial infarction patients was associated with significantly higher serum AA/EPA ratios compared to non-depressed patients, with no significant difference in CRP levels.
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