Key result
Major depression 2 months post-acute coronary syndrome was associated with significantly higher sICAM-1 levels and, in patients not on statins, markedly higher C-reactive protein levels.
Why the study?
Is major depression associated with higher levels of inflammatory markers in patients recovering from acute coronary syndromes?
Observational (n=481)
Is major depression associated with higher levels of inflammatory markers in patients recovering from acute coronary syndromes?
Major depression is associated with chronic endothelial activation and higher inflammatory markers (sICAM-1 and CRP) in patients recovering from acute coronary syndromes, particularly those not on statin therapy.
No takes yet. Share an insight, caveat, or question.
Association does not support practice change in post-ACS care; leaves open causal mechanisms and interventional trials.
Lespérance et al. (2004) conducted an observational in Acute coronary syndromes (n=481). Major depression vs. No major depression was evaluated on Levels of sICAM-1, IL-6, and C-reactive protein. Major depression 2 months post-acute coronary syndrome was associated with significantly higher sICAM-1 levels and, in patients not on statins, markedly higher C-reactive protein levels.
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