Key result
Among adults undergoing surgery for acute appendicitis, 11.11% presented with normal leukocyte and CRP levels, which was significantly associated with rural origin and self-medication.
Why the study?
What factors are associated with normal leukocyte count and C-reactive protein in adults with acute appendicitis?
Cohort (n=333)
What factors are associated with normal leukocyte count and C-reactive protein in adults with acute appendicitis?
In adults with acute appendicitis, 11.11% present with normal inflammatory parameters, which is significantly associated with rural origin and self-medication.
May help flag atypical appendicitis presentations; leaves open whether normal labs should modify diagnostic thresholds.
OBJECTIVE: To identify the factors associated with normal leukocyte count and C-reactive protein (CRP) in adults with acute appendicitis. MATERIAL AND METHODS: A retrospective cohort study included patients aged 18-60 years after surgeries for acute appendicitis. Convenience sampling was used to select medical records, and variables such as age, sex, weight, height, origin, self-medication, diabetes (DM2), high blood pressure (HBP), type of appendicitis, duration of illness, preoperative time, type of appendectomy, operative time, and hospital stay were analyzed. Patients were categorized into those with normal and abnormal inflammatory parameters. The SPSS version 28 software was used for analysis. RESULTS: We included 333 patients; 11.11% ones had normal inflammatory parameters. Both groups had mean age of approximately 33 years. Men comprised 56.76% and 57.43%in both groups, respectively. The abnormal group had shorter mean preoperative time, and catarrhal appendicitis was more common in the normal group. Multivariate analysis revealed that rural origin and self-medication were significantly associated with normal inflammatory parameters. CONCLUSION: The prevalence of normal inflammatory parameters in acute appendicitis patients was 11.11%. Rural origin, self-medication, shorter preoperative time, and catarrhal appendicitis were significantly associated with normal inflammatory parameters in this context.
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Yamir et al. (2024) conducted a cohort in acute appendicitis (n=333). Rural origin and self-medication was evaluated on Normal leukocyte count and C-reactive protein (CRP). Among adults undergoing surgery for acute appendicitis, 11.11% presented with normal leukocyte and CRP levels, which was significantly associated with rural origin and self-medication.
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