Key result
Novel metric links stellate ganglion neuronal population dynamics directly to near-peak systolic mechanical events.
Why the study?
Activity of stellate ganglion neurons is often linked indirectly to cardiac function, necessitating direct metrics linking neuronal dynamics to cardiopulmonary physiology.
A novel metric allows for the probing of stellate ganglion neuronal control of cardiopulmonary function by linking neuronal dynamics to mechanical events.
May enable mechanistic probing of stellate ganglion-cardiac coupling in large animals; leaves open translation to human autonomic therapies.
Activity of stellate ganglion neurons is often linking indirectly to cardiac function. Using novel approaches coupled with extended period of recordings in large animals, we link neuronal population dynamics to mechanical events occurring at near-peak systole. This metric can be deployed to probe stellate ganglion neuronal control of cardiopulmonary function in normal and disease states.
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Sudarshan et al. (2021) studied this question. A novel metric derived from extended recordings links stellate ganglion neuronal population dynamics directly to mechanical events occurring at near-peak systole in large animals.
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