Key result
Porcine sapovirus was the primary RNA virus in piglet feces (27.54%), with the prevalent strain SHCM/Mega2023 belonging to the GIII genogroup and undergoing purifying selection.
The study identifies the genomic evolution and selective pressure of a novel Porcine Sapovirus in Shanghai, providing insights for antigenicity and vaccine research.
Porcine sapovirus (PoSaV) is a significant pathogen causing diarrhea with high morbidity and mortality rates. Given its zoonotic characteristics, this study conducts a comprehensive genetic evolutionary analysis of PoSaV. Results confirmed PoSaV as the primary RNA virus in piglet feces (27.54%). Phylogenetic analysis identifies the prevalent PoSaV strain SHCM/Mega2023 in the GIII genogroup, involving a recombinant event with MK962338 and KT922089. The time tree revealed that the GIII genogroup exhibits the widest divergence time span, indicating a high likelihood of viral recombination. Further selective pressure calculations demonstrate that PoSaV was under purifying selection (dN/dS < 1), with seven positively selected sites in VP1 protein which might be related to the antigencity. In conclusion, this study presents a novel genomic evolution of PoSaV, offering valuable insights into antigenicity and vaccine research.
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Tao et al. (2024) studied Porcine sapovirus (PoSaV) infection. Porcine sapovirus (PoSaV) was evaluated on PoSaV prevalence in piglet feces. Porcine sapovirus was the primary RNA virus in piglet feces (27.54%), with the prevalent strain SHCM/Mega2023 belonging to the GIII genogroup and undergoing purifying selection.
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