Key result
Serum 25-(OH)D levels were significantly lower in T2DM patients with NAFLD compared to those without, and lower levels independently predicted the degree of liver fibrosis.
Why the study?
Are serum 25-hydroxyvitamin D levels associated with nonalcoholic fatty liver disease and liver fibrosis in Chinese patients with type 2 diabetes mellitus?
Cross-Sectional (n=300)
Are serum 25-hydroxyvitamin D levels associated with nonalcoholic fatty liver disease and liver fibrosis in Chinese patients with type 2 diabetes mellitus?
Low serum 25-hydroxyvitamin D levels are associated with the presence of NAFLD and the degree of liver fibrosis in Chinese patients with type 2 diabetes mellitus.
Low vitamin D may correlate with NAFLD in T2DM; leaves open whether supplementation modifies risk or fibrosis.
PURPOSE: We aimed to analyze the serum vitamin D level in Chinese patients with type 2 diabetes mellitus (T2DM) and discuss its correlation with nonalcoholic fatty liver disease (NAFLD). PATIENTS AND METHODS: A total of 300 patients with T2DM (92 patients without NAFLD and 208 patients with NAFLD) were enrolled, and 25-hydroxyvitamin D [25-(OH)D] levels were compared between the two groups. Second, the NAFLD fibrosis score (NFS) and fatty liver index (FLI) were used to group patients with T2DM complicated by NAFLD, and the differences in serum 25-(OH)D in patients with different degrees of liver fibrosis were compared. Third, multiple regression analysis was used to analyze the independent predictors of liver fibrosis in patients with T2DM complicated by NAFLD. RESULTS: The level of 25-(OH)D in patients with T2DM complicated by NAFLD was significantly lower than that in patients with T2DM alone. Based on the NFS and FLI, the 25-(OH)D level of the hepatic fibrosis subgroup was significantly lower than that of the subgroup without liver fibrosis. 25-(OH)D was found to be an independent predictor of liver fibrosis in patients with T2DM complicated by NAFLD. CONCLUSION: The serum 25-(OH)D level in patients with T2DM complicated by NAFLD was significantly reduced, and the 25-(OH)D level showed a gradual downward trend with the degree of liver fibrosis. Low concentrations of 25-(OH)D may be indicative of the degree of liver fibrosis in diabetic patients.
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Xiu et al. (2021) conducted a cross-sectional in Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease (n=300). Serum 25-hydroxyvitamin D [25-(OH)D] level vs. T2DM patients without NAFLD was evaluated on Presence of nonalcoholic fatty liver disease and degree of liver fibrosis. Serum 25-(OH)D levels were significantly lower in T2DM patients with NAFLD compared to those without, and lower levels independently predicted the degree of liver fibrosis.
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