The Aldol Type Reaction Catalyzed by Arylmalonate Decarboxylase —A Decarboxylase can Catalyze an Entirely Different Reaction, Aldol Reaction—

The catalytic promiscuity of AMDase was demonstrated using a well-designed substrate based on the consideration of the reaction mechanism. As the reaction catalyzed by AMDase is supposed to proceed via an enolate intermediate, we expected that the enzyme promotes the aldol type reaction when an acceptor is properly arranged, which turned out to be true.