Answers are grounded in this paper and cite their sources.
To map out the stoichiometric ligand requirements in the two-ligand catalytic asymmetric deprotonation of N-Boc pyrrolidine, 24 different ligands have been evaluated; the highest enantioselectivity (90:10 er) was obtained by using s-BuLi in the presence of 0.3 equiv of (-)-sparteine and 1.3 equiv of a cyclohexanediamine-derived ligand.
No takes yet. Share an insight, caveat, or question.
Bilke et al. (2008) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: