Key result
Combined biomarker score predicts 30-day mortality after ATAAD surgery with an AUC of ~0.85.
Why the study?
The prognostic value of inflammatory markers for in-hospital mortality and renal complications after surgery for acute type A aortic dissection was unclear.
Do inflammatory biomarkers predict adverse outcomes in patients undergoing surgery for acute type A aortic dissection?
Population
328 patients undergoing surgery for acute type A aortic dissection
Comparison
Serum inflammatory biomarkers measured at admission and postoperative days 1, 2, and 7
Design
Cohort study
Follow-up
30 days
Authors
Loading...
Combined biomarker score may aid risk stratification after ATAAD repair; leaves open need for prospective validation before clinical adoption.
Cohort (n=328)
Do inflammatory biomarkers predict adverse outcomes in patients undergoing surgery for acute type A aortic dissection?
Effect estimate: AUC 0.849
p-value: p=<0.001
Procalcitonin and cytokines such as IL-2R and IL-6 serve as early predictors for mortality and severe acute kidney injury following surgery for acute type A aortic dissection.
Liu et al. (2019) conducted a cohort in Acute type A aortic dissection (ATAAD) (n=328). Inflammatory biomarkers (PCT, IL-2R, IL-6, IL-8, TNF-α) was evaluated on 30-day mortality and stage III AKI (AUC 0.849, p=<0.001). A combined biomarker score including PCT, IL-2R, IL-6, and APACHE II predicted 30-day mortality with an area under the ROC curve of 0.849 in patients undergoing surgery for ATAAD.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: