Key result
Previous malignant hypertension is linked to depressed T-cell frequency and impaired mitogen proliferative response.
Why the study?
The extent to which the immune system is influenced in patients with previous malignant hypertension was investigated.
Are immune mechanisms altered in patients with previous malignant hypertension compared to control subjects?
Comparison
Patients with malignant hypertension vs control subjects
Design
Observational study
Follow-up
3-year period
Authors
Loading...
Immune alterations observed in prior malignant hypertension warrant no clinical action; leaves open primary versus secondary role in vascular injury.
Observational (n=23)
Are immune mechanisms altered in patients with previous malignant hypertension compared to control subjects?
Patients with previous malignant hypertension exhibit abnormal cellular immune function and increased autoantibodies, suggesting immune mechanisms are involved in the condition.
Hilme et al. (1993) conducted an observational in Malignant hypertension (n=23). Malignant hypertension vs. Control subjects was evaluated on Function of the cellular immune system (number of T lymphocytes and proliferative response to T-cell mitogens), human leucocyte antigens, and frequency of autoantibodies. Patients with previous malignant hypertension had significantly depressed T lymphocyte frequency and baseline thymidine incorporation compared with control subjects.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: