Key result
Genetic biomarkers play a crucial role in the diagnosis, prognosis, and prediction of response to anti-TNF therapy in rheumatoid arthritis, which is effective in 60-70% of patients.
Why the study?
What is the current role of genetic biomarkers in diagnosis, prognosis, and predicting response to anti-TNF therapy in rheumatoid arthritis?
What is the current role of genetic biomarkers in diagnosis, prognosis, and predicting response to anti-TNF therapy in rheumatoid arthritis?
Genetic biomarkers hold potential as theranostic tools to predict response to anti-TNF therapy in rheumatoid arthritis, addressing the clinical need to identify the 60-70% of patients who will benefit.
Does not yet support routine genetic testing to guide anti-TNF therapy in RA; leaves open theranostic potential pending prospective validation.
The identification and adoption of diagnostic and prognostic biomarkers for rheumatoid arthritis has informed and improved the clinical management of this disease.With the advent of biologic treatments such as anti-Tumour Necrosis Factor (anti-TNF) therapy, achieving disease remission has become a realistic endpoint for clinicians.The life-changing efficacy of these therapies however is restricted to the 60-70% of patients who respond.The immune reaction to anti-inflammatory therapy is thought to be influenced by many genes which cumulatively contribute to a threshold for response.There is an inherent clinical need to provide theranostic biomarkers which could determine treatment outcome.The current role of genetic biomarkers in diagnosis, prognosis and predicting response to anti-TNF therapy are discussed.
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Cathy M. McGeough (2013) conducted a review in Rheumatoid arthritis. Genetic biomarkers was evaluated. Genetic biomarkers play a crucial role in the diagnosis, prognosis, and prediction of response to anti-TNF therapy in rheumatoid arthritis, which is effective in 60-70% of patients.
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