Unsymmetrical covariance processing of COSY or TOCSY and HSQC NMR data to obtain the equivalent of HSQC‐COSY or HSQC‐TOCSY spectra

Abstract magnified image Artifacts observed in the indirect covariance NMR spectrum of HSQC‐TOCSY data have recently been analyzed and a method for their elimination proposed. More recently, unsymmetrical covariance processing has been applied HSQC and HMBC spectral data to afford long‐range carbon‐carbon correlation information equivalent to that obtained from n, 1‐, 1, n‐ and m,n‐ADEQUATE spectra. We now wish to describe the results obtained through the application of unsymmetrical covariance processing of HSQC and COSY or TOCSY data, which affords the equivalent of HSQC‐COSY and HSQC‐TOCSY data in a fraction of the time required to record these spectra directly and with considerably higher sensitivity.