Key result
In NSCLC patients with lymph node metastasis, MMP-1 and MMP-2 overexpressions were independent prognostic factors associated with decreased survival (p=0.0015 and p=0.011, respectively).
Authors
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May refine metastatic NSCLC prognostication via MMP profiling; leaves open prospective validation before clinical adoption.
Cohort (n=472)
p-value: p=0.0015
Lin et al. (2004) conducted a cohort in Non-small cell lung cancer (n=472). MMP-1 and MMP-2 overexpression vs. No overexpression was evaluated on Decreased survival (p=0.0015). In NSCLC patients with lymph node metastasis, MMP-1 and MMP-2 overexpressions were independent prognostic factors associated with decreased survival (p=0.0015 and p=0.011, respectively).
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