Key result
Delayed sternal closure after cardiac surgery yields ~58% 30-day survival, highest when indicated for coagulopathy.
Why the study?
Delayed sternal closure is used to manage hemodynamic instability and perioperative coagulopathy after cardiac surgery, but long-term outcomes and quality of life data are limited.
Cohort (n=227)
No
Delayed sternal closure following cardiac surgery has an overall 30-day survival of 57.5%, with low cardiac output syndrome being a major negative prognostic factor, though survivors demonstrate good long-term quality of life.
May inform risk stratification for delayed sternal closure; leaves open prospective trials to refine indication-specific use.
Delayed sternal closure (DSC) is a well-established strategy used to manage patients with hemodynamic instability and perioperative coagulopathy following cardiac surgery. The study aims to present our 15-year surgical experiences with DSC.Between 2007 and 2022, DSC was performed in 227 out of 14,210 patients (1.7%) who underwent cardiac surgery at our institution. Perioperative data, outcomes, and long-term survival were analyzed. Quality of life (QoL) was assessed utilizing the EuroQol-5D-5L questionnaire.Indications for DSC included low cardiac output syndrome (LCOS) (44.1%) and coagulopathy during the index procedure (32.2%), as well as postoperative tamponade (22.9%). In coronary artery bypass grafting, LCOS was the primary indication for DSC (72.7%), whereas in acute type A aortic dissection, coagulopathy was the leading indication (70.6%). For other procedures, DSC indications were more evenly distributed. The overall 30-day survival was 57.5%, with survival rates of 43.3% for LCOS, 72.0% for coagulopathy, and 65.4% for tamponade. Multivariate logistic regression identified body mass index, postoperative renal replacement therapy, aggravated heart failure, and intraoperative packed red blood cell transfusion as negatively associated with 30-day survival. The mean follow-up period was 6.58 ± 3.19 years. Younger patients and DSC patients upon bleeding related indications reported higher QoL in comparison to older patients and patients with LCOS. Longer follow-up interval correlated with higher QoL.The study emphasizes the significant impact of LCOS on outcomes in patients undergoing DSC. We provide QoL data demonstrating good rehabilitation potential upon survival of the acute phase.
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Song et al. (2025) conducted a cohort in Hemodynamic instability and perioperative coagulopathy following cardiac surgery (n=227). Delayed sternal closure was evaluated on 30-day survival. Delayed sternal closure following cardiac surgery resulted in an overall 30-day survival of 57.5%, with survival rates varying by indication (43.3% for low cardiac output syndrome vs 72.0% for coagulopathy).
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