Key result
Five monoclonal antibodies generated against the TGEV CTD protein exhibited in vitro neutralizing activity, effectively inhibiting TGEV infection and replication in swine testicular cells.
Population
Balb/c mice, HEK-293 F suspension cells, HEK-293T cells, and swine testicular (ST) cells
Design
Preclinical
Authors
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Supplies in vitro neutralizing reagents for TGEV studies; leaves open translation to in vivo protection or diagnostics in swine.
The study successfully generated TGEV-specific monoclonal antibodies with in vitro neutralizing activity, providing tools for TGEV research and diagnostic development.
Song et al. (2025) studied Porcine Transmissible Gastroenteritis Virus (TGEV). Monoclonal antibodies against TGEV CTD protein was evaluated on In vitro neutralizing activity against TGEV. Five monoclonal antibodies generated against the TGEV CTD protein exhibited in vitro neutralizing activity, effectively inhibiting TGEV infection and replication in swine testicular cells.