Co-infection With Pandemic H1N1 and Seasonal H3N2 Influenza Viruses

Letters4 May 2010Co-infection With Pandemic H1N1 and Seasonal H3N2 Influenza VirusesNelson Lee, MBBS, MD, Paul K.S. Chan, MBBS, MD, Wai-yip Lam, PhD, Cheuk-chun C. Szeto, MBChB, MD, and David S.C. Hui, MBBS, MDNelson Lee, MBBS, MDFrom Chinese University of Hong Kong, Shatin, Hong Kong, China., Paul K.S. Chan, MBBS, MDFrom Chinese University of Hong Kong, Shatin, Hong Kong, China., Wai-yip Lam, PhDFrom Chinese University of Hong Kong, Shatin, Hong Kong, China., Cheuk-chun C. Szeto, MBChB, MDFrom Chinese University of Hong Kong, Shatin, Hong Kong, China., and David S.C. Hui, MBBS, MDFrom Chinese University of Hong Kong, Shatin, Hong Kong, China.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-9-201005040-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: One immediate concern about the current influenza pandemic is whether the virus will further reassort with other cocirculating influenza subtypes in humans or an intermediate host (1, 2). However, despite annual cocirculation of different subtypes of influenza A viruses, dual infection has rarely been reported (3). In Hong Kong, there are 2 seasonal peaks of influenza activity. In 2009, the summer peak for seasonal influenza coincided with the first wave of the pandemic (4).Objective: To report the first documented dual infection of pandemic (H1N1) 2009 and seasonal H3N2 viruses in a human.Case Report: We managed a 38-year-old ...References1. Zimmer SM, Burke DS. Historical perspective—Emergence of influenza A (H1N1) viruses. N Engl J Med. 2009;361:279-85. [PMID: 19564632] CrossrefMedlineGoogle Scholar2. Nelson MI, Viboud C, Simonsen L, Bennett RT, Griesemer SB, St George K, et al. Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918. PLoS Pathog. 2008;4:e1000012. [PMID: 18463694] CrossrefMedlineGoogle Scholar3. Falchi A, Arena C, Andreoletti L, Jacques J, Leveque N, Blanchon T, et al. Dual infections by influenza A/H3N2 and B viruses and by influenza A/H3N2 and A/H1N1 viruses during winter 2007, Corsica Island, France. J Clin Virol. 2008;41:148-51. [PMID: 18069055] CrossrefMedlineGoogle Scholar4. Centre for Health Protection. Influenza page. Accessed at www.chp.gov.hk/view_content.asp?lang=en&info_id=14843 on 25 February 2010. Google Scholar5. Centers for Disease Control and Prevention. Vaccine Information for Clinicians and Health Care Professionals—ACIP 2009 H1N1 Influenza Vaccine Recommendations. Accessed at www.cdc.gov/h1n1flu/vaccination/professional.htm on 25 February 2010. Google Scholar Author, Article, and Disclosure InformationAffiliations: From Chinese University of Hong Kong, Shatin, Hong Kong, China.Disclosures: None disclosed. 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