Adrenal Suppression in Disseminated Carcinoma of the Breast

AN underlying or implied purpose in several steps commonly used for the treatment of patients with disseminated carcinoma of the breast is to free the body fluids of estrogenic substances. This purpose does not relate so much to the demonstration that the tumors found in most patients under the age of sixty-five are stimulated by small doses of estrogens, as it does to the empirical fact that the removal of estrogen-producing endocrine glands is often associated with dramatic improvement in the patient and objective remission of the disease.Removal of the ovaries by oophorectomy does not reduce to zero the . . .