Key result
Treatment of GH-deficient spontaneous dwarf rats with growth hormone rapidly and markedly increased white adipose tissue resistin mRNA expression by up to 950% at 24 hours.
Why the study?
Does growth hormone treatment increase resistin gene expression in white adipose tissue of GH-deficient rats?
Does growth hormone treatment increase resistin gene expression in white adipose tissue of GH-deficient rats?
Growth hormone rapidly and markedly up-regulates resistin gene expression in white adipose tissue of GH-deficient rats, suggesting a potential mechanism for GH-induced insulin resistance.
Authors
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GH deficiency suppresses resistin in rodent WAT; hypothesis-generating for human metabolic effects, prospective studies required.
Delhanty et al. (2002) studied Growth hormone deficiency. Growth hormone (recombinant human or porcine) vs. Controls was evaluated on White adipose tissue (WAT) resistin gene expression (mRNA). Treatment of GH-deficient spontaneous dwarf rats with growth hormone rapidly and markedly increased white adipose tissue resistin mRNA expression by up to 950% at 24 hours.