Key result
High delivery risk linked to ~3-fold higher Toxoplasma seropositivity versus normal pregnancy controls.
Why the study?
The incidence of TORCH infections in women with history of pregnancy loss and high delivery risk factors was not well characterized in a tertiary care setting.
Is there a higher prevalence of TORCH infections in women with high delivery risk factors compared to women with normal pregnancies?
Observational (n=150)
No
Is there a higher prevalence of TORCH infections in women with high delivery risk factors compared to women with normal pregnancies?
Absolute Event Rate: 41% vs 14%
Maternal TORCH infections are highly prevalent in women with high delivery risk factors compared to healthy controls, highlighting the potential value of targeted screening in this population.
Seropositivity supports targeted TORCH testing in HDRF women; leaves open whether screening improves pregnancy outcomes.
OBJECTIVE: To evaluate the incidence of TORCH infections in women having history of pregnancy loss and women with high delivery risk factors (HDRF) in tertiary care hospital.Duration: A prospective study was conducted over a period of one year from January 2013 to December2013. METHODS:The study included 100 women with HDRF and 50 clinically normal women with previous normal pregnancy and full term deliveries.Serological evaluation for TORCH infections was carried out by IgG and IgM ELISA method.RESULTS: The acronym TORCH (Toxoplasma, Other infections, Rubella, Cytomegalovirus, Herpes simplex virus) was introduced to highlight a group of agents which cause congenital and perinatal infections.The prevalence of TORCH infections in tertiary care hospital was studied over a period of one year.Since majority of congenital infections result from maternal infections during pregnancy, it was essential to evaluate the incidence of maternal infection like TORCH in child bearing age group.The present study showed toxoplasmosis was with a high risk seropositivity rate of 41%, followed by 27% seropositivity for Cytomegalovirus (CMV) .Rubella infections still occur each year and it occurred in 18 % cases while Herpes simplex virus infection was comparatively low seen only in 14% cases among women of child-bearing age.But unfortunately the request for TORCH screening has been ignored and clinicians should be encouraged to send appropriate specimens for specific tests depending on the clinical features of the individual case so as to reduce the adverse fetal outcome.
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Suryawanshi et al. (2014) conducted an observational in High delivery risk factors (pregnancy loss, intrauterine growth retardation, intrauterine deaths, preterm labour, early neonatal death, congenital malformation) (n=150). High delivery risk factors vs. Clinically normal women with previous normal pregnancy and full term deliveries was evaluated on Toxoplasma gondii IgM seropositivity. Among women with high delivery risk factors, the seropositivity rate for Toxoplasma was 41%, Cytomegalovirus 27%, Rubella 18%, and Herpes simplex virus 14%, compared to lower rates in healthy controls.
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