Key result
Melatonin normalizes key vascular biomarkers comparable to atorvastatin in hypercholesterolemic rats.
Why the study?
The effects of melatonin on endothelial function and inflammation in hypercholesterolemic conditions were not fully understood.
Does melatonin improve endothelial dysfunction and inflammation in hypercholesterolemic rats?
Does melatonin improve endothelial dysfunction and inflammation in hypercholesterolemic rats?
Melatonin demonstrates protective and therapeutic effects against hypercholesterolemia-induced endothelial dysfunction and inflammation in a rat model, with efficacy comparable to atorvastatin.
Should not yet change practice in hypercholesterolemia; leaves open translation of melatonin's effects from rat models to humans.
The aim of this study was to investigate the effects of melatonin on the serum asymmetric dimethylarginine (ADMA) levels and the expressions of vaspin, visfatin, dimethylarginine dimethylaminohydrolase (DDAH), and signal transducer and activator of transcription-3 (STAT-3) for evaluation of endothelial function and inflammation in the hypercholesterolemic rats. Rats were divided into 5 groups: (1) control, (2) hypercholesterolaemia, (3) melatonin administrated concurrently with cholesterol diet, (4) melatonin administrated only last 2 weeks and fed with cholesterol diet, (5) atorvastatin administered only last 2 weeks fed with cholesterol diet. Although an increase was observed in the expressions of visfatin and STAT-3 and the serum ADMA levels, the vaspin and DDAH protein expressions were found to decrease with hypercholesterolemic diets. Melatonin was determined to restore all the parameters to the normal levels. In conclusion, melatonin may have protective and therapeutic effects on hypercholesterolaemia by regulating vaspin, STAT-3, DDAH, and ADMA signalling pathways and create similar effects with atorvastatin.
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Sezgin et al. (2020) studied Hypercholesterolemia. Melatonin vs. Control, hypercholesterolemia alone, and atorvastatin was evaluated on Serum ADMA levels and expressions of vaspin, visfatin, DDAH, and STAT-3. Melatonin restored serum ADMA, vaspin, visfatin, DDAH, and STAT-3 to normal levels in hypercholesterolemic rats, demonstrating protective effects similar to atorvastatin.
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