Key result
Young adult stroke incidence rises from 1993 to 2020 alongside declining 30-day fatality rates.
Why the study?
The burden of stroke may be rising in young adults despite an overall decline in incidence rate, necessitating characterization of incidence, fatality, and risk factors over time.
Observational
Yes
Answers are grounded in this paper and cite their sources.
The incidence of stroke in young adults (20-54 years) is rising over time, coinciding with increased traditional vascular risk factors and substance use, despite a decline in 30-day case fatality rates.
BACKGROUND AND OBJECTIVES: Despite an overall decline in incidence rate, the burden of stroke may be rising in young adults. We aimed to characterize the incidence rates, 30-day case fatality rates (CFRs), and the burden of stroke risk factors over time in young adults in a representative population-based study of stroke. METHODS: Using validated methods, hospitalized stroke cases in a 5-county region were ascertained and adjudicated by stroke-trained physicians in 6 study periods: July 1993-June 1994 and calendar years 1999, 2005, 2010, 2015, and 2020. Stroke in the young was defined as those occurring among individuals who were aged 20-54 years. Incidence rates were generated using US Census data standardized to the 2010 population, and trends were tested with linear regression. Temporal trends in 30-day CFR were evaluated with logistic regression after adjusting for age, race, and sex. DISCUSSION: The incidence of stroke in young adults is rising over time, while the CFR simultaneously declines. This coincides with a rise in both traditional vascular risk factors and substance use.
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Fisher et al. (2026) conducted an observational in Stroke. Time (calendar year) was evaluated on Incidence rates and 30-day case fatality rates (p== 0.09). The incidence of stroke in young adults aged 20-54 years increased over time from 1993 to 2020, while the 30-day case fatality rate simultaneously declined.
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