Key result
Marathon running is linked to a ~4% drop in peak VO2 alongside transient pulmonary inflammation.
Why the study?
Endurance exercise induces skeletal muscle, heart, and respiratory fatigue with morphofunctional cardiac changes and reduced maximal ventilation and oxygen consumption, but the relationship with exhaled nitric oxide and pulmonary inflammation after marathon is unclear.
Does running a marathon impair cardiopulmonary function and alter exhaled nitric oxide levels in male marathoners?
Population
31 male marathoners, age 39±9 years
Comparison
Post-marathon measurements vs baseline pre-marathon
Design
Observational cohort study
Follow-up
Up to 15 days after marathon
Authors
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May warrant caution in post-marathon recovery monitoring; hypothesis-generating for nitric oxide and inflammation effects, needing prospective validation.
Observational (n=31)
Does running a marathon impair cardiopulmonary function and alter exhaled nitric oxide levels in male marathoners?
p-value: p=<0.05
Marathon running induces acute pulmonary inflammation and transiently impairs cardiopulmonary capacity, which correlates with changes in exhaled nitric oxide bioavailability.
Sierra et al. (2019) conducted an observational in Healthy marathon runners (n=31). Marathon running vs. Pre-marathon baseline was evaluated on Cardiopulmonary capacity (peak VO2) and exhaled nitric oxide levels (p=<0.05). Marathon running reduced cardiopulmonary capacity, decreasing peak VO2 from 57 to 55 mL/min/kg (p<0.05), and induced transient changes in exhaled nitric oxide and pulmonary inflammation.
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