Key result
Higher 24-hour ambulatory SBP is strongly linked to impaired GLS on echocardiography.
Why the study?
Ambulatory blood pressure thresholds at which echocardiographic indices of left ventricular size and function start to be affected were not well defined.
What is the optimal ambulatory blood pressure threshold at which echocardiographic indices of left ventricular size and function start to be affected?
Cross-Sectional (n=78)
No
What is the optimal ambulatory blood pressure threshold at which echocardiographic indices of left ventricular size and function start to be affected?
Effect estimate: correlation coefficient 0.772
p-value: p=<0.001
A 24-hour systolic ambulatory blood pressure threshold of >140 mmHg is strongly correlated with early echocardiographic changes including LV hypertrophy, LA dilatation, and impaired global longitudinal strain.
May define ABPM thresholds for LV changes; hypothesis-generating and requires prospective validation before clinical adoption.
Іntroductіon: Hypertension is a leading cause of stroke, coronary artery disease, heart failure and premature death around the world. Ambulatory blood pressure monitoring (ABPM) calculates the average of BP readings over a set period of time, and its values have been proven to be more closely related to the left ventricular mass (LVM) . Aіm:This study aimed at finding ambulatory Blood pressure thresholds at which Echocardiographic indices of Left Ventricle Size and function start to be affected .Matеrіal & Mеthods. This study was conducted on seventy eight patients visiting cardiology clinic of Suez Canal hospital . Rеsults.This cross-sectional study included 78 patients , the mean age was 55 years( from 21 to 70 years). Subjects with significantly higher systolic BP averages found with dilated left atrium , significant higher average SBP found with impaired GLS compared with those with normal SBP readings who were found to have normal GLS . There was a strong correlations between ambulatory BP readings and Echocardiographic changes including LVH , Left atrial dilatation and impaired GLS , correlations were more stronger in GLS impairment rather than LVH and LA dilatation (correlation coefficient: 0.772,P<0.001). Systolic blood pressure averages showed stronger correlations with LVH, LA dilatation and GLS impairment than diastolic averages . The determined optimal ABPM threshold in this study at which cardiac changes (LVH, LA dilatation or GLS impairment) occur is > 140 mmHg for 24-hour SBP. Conclusіon. Higher ambulatory BP thrersholds were significantly associated with hypertension, LA dilatation, LV hypertrophy and impaired GLS in subjects with normal LVEF. The thresholds at which these cardiac changes start to manifest are higher than the established ABPM normal values, which was found to be > 140 mmHg in 24-SBP.
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Hassan et al. (2025) conducted a cross-sectional in Hypertension (n=78). Ambulatory blood pressure vs. Normal ambulatory blood pressure was evaluated on Correlation between ambulatory BP readings and echocardiographic changes (LVH, LA dilatation, impaired GLS) (correlation coefficient 0.772, p=<0.001). Higher ambulatory blood pressure readings (>140 mmHg for 24-hour SBP) were strongly correlated with echocardiographic changes, particularly impaired global longitudinal strain (r=0.772, P<0.001).
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