Key result
Post-IHD depression is linked to marked apathy and distinct molecular-genetic profiles versus other psychogenic depression.
Why the study?
Psychometric and molecular-genetic differences between depression caused by ischemic heart disease and depression caused by other psychogenic factors in patients with IHD were not well characterized.
Does the etiology of depression (IHD-induced vs other psychogenic factors) affect psychometric and molecular-genetic profiles in patients with IHD?
Observational (n=135)
Does the etiology of depression (IHD-induced vs other psychogenic factors) affect psychometric and molecular-genetic profiles in patients with IHD?
Depression directly associated with IHD presents with a distinct psychometric profile of marked apathy and specific molecular-genetic correlates compared to depression from other causes in IHD patients.
Distinct apathy-dominant profile with specific genetic markers marks IHD-linked depression; leaves open subtype-specific management pending replication.
OBJECTIVE: To compare psychometric and molecular-genetic characteristics of depression caused by ischemic heart disease (IHD) and depression in patients with IHD caused by other psychogenic factors. MATERIAL AND METHODS: One hundred and thirty-five patients with depression comorbid to ischemic heart disease (IHD) were examined. Depression was associated with IHD in 71 patients (group 1). In 64 patients, depression was caused by other psychogenic factors (group 2). The HAMD-21 scale was used to measure depressive symptoms. RESULTS AND CONCLUSION: The comparative analysis of the core symptoms of depression demonstrated that group 1 had a peculiar psychometric profile with marked apathy, which was not accompanied by marked hypothymia, guilt feelings or anxiety, compared to group 2. The molecular-genetic correlate of this profile was found. It included a combination of an allele S (5-HTTLPR) of the serotonin transporter gene, an allele G (A-1438G) of the serotonin receptor type 2A gene and the genotype ValVal (Val66Met) of the brain-derived neurotrophic factor gene.
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Голимбет et al. (2015) conducted an observational in Depression comorbid to ischemic heart disease (n=135). Depression caused by ischemic heart disease vs. Depression caused by other psychogenic factors was evaluated on Psychometric profile (HAMD-21) and molecular-genetic characteristics. Depression caused by IHD (n=71) was associated with marked apathy and specific molecular-genetic correlates compared to depression from other psychogenic factors (n=64).
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