Why the study?
The study was conducted to analyze available scientific publications on the clinical and genetic aspects of depressive disorders in patients with coronary heart disease.
This review highlights the clinical complexity and prognostic impact of comorbid depression in CHD patients, emphasizing the need for further research into its genetic markers.
Comorbid depression complicates CHD management; leaves open genetic marker roles pending targeted studies.
Objective : to analyze available scientific publications on the problem of clinical and genetic aspects of depressive disorders in patients with coronary heart disease (CHD). Material and methods : by keywords “coronary heart disease”, “mental disorders”, “depression”, “genetics”, “genetic markers”, “polymorphism”, “personality” articles in English and Russian were searched in the MEDLINE/PubMed, Scopus, Web of science, eLibrary databases in the period from 2020 to 2021. Conclusion : depression comorbid CHD is considered as a clinical problem due to its high prevalence, as well as its influence on the features of the course and prognosis of CHD, as well as on the compliance of patients. Heterogeneity of the clinical structure of depressive disorders in CHD (nosogenic, endogenomorphic, endogenous, somatogenic depression) causes difficulties in differential diagnosis and complex therapeutic measures. There are several factors contributing to the onset of depression in CHD patients: biological, clinical, personal characteristics. Genetic markers of depression in CHD, which have prognostic value, require further clarification.
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Dolzhikov et al. (2023) studied this question.
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