Key result
A coronary heart disease genetic risk score was not significantly associated with depression risk (1% increase; 95% CI 0-3%; p=0.11), suggesting comorbidity arises from shared environmental factors.
Why the study?
While comorbidity between coronary heart disease and depression is evident, it remains unclear whether the two diseases have shared underlying mechanisms.
Are cardiovascular risk factors and coronary heart disease causally related to depression in middle-aged adults?
Cohort (n=367,703)
Are cardiovascular risk factors and coronary heart disease causally related to depression in middle-aged adults?
Effect estimate: 1% increase (95% CI 0% to 3%)
p-value: p=0.11
Comorbidity between depression and coronary heart disease likely arises from shared environmental factors, though specific inflammatory and lipid markers (IL-6, CRP, triglycerides) may be causally linked to depression.
No takes yet. Share an insight, caveat, or question.
Should not alter clinical screening based on CHD genetics; leaves open shared environment and biomarker causality for future studies.
Khandaker et al. (2019) conducted a cohort in Coronary heart disease and depression (n=367,703). Coronary heart disease genetic risk score was evaluated on Depression risk per standard deviation increase in CHD genetic risk score (1% increase, 95% CI 0% to 3%, p=0.11). A coronary heart disease genetic risk score was not significantly associated with depression risk (1% increase; 95% CI 0-3%; p=0.11), suggesting comorbidity arises from shared environmental factors.
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