Key result
Moxibustion at 46°C improves cardiac function and increases mast cell degranulation over 38°C in bradycardia.
Why the study?
The effects of thermal stimulation by moxibustion at different temperatures on cardiac function and local mast cells in a brachycardia rat model were unclear.
Does thermal stimulation by moxibustion at 46°C improve cardiac function more than 38°C in a brachycardia rat model?
Does thermal stimulation by moxibustion at 46°C improve cardiac function more than 38°C in a brachycardia rat model?
p-value: p=< 0.05
Moxibustion at 46°C provides greater improvement in cardiac function and local mast cell degranulation than 38°C in a propranolol-induced brachycardia rat model.
Moxibustion temperature effects on rat bradycardia are hypothesis-generating; leaves open any role in human cardiac care.
Objective. To observe effects of the thermal stimulation by moxibustion at different temperatures on cardiac function in brachycardia rat model and on mast cells in the local site of moxibustion at the Ximen Acupoint and to compare the differences of the effects of moxibustion at different temperatures. Method. Establish the brachycardia rat model with propranolol and observe effects of the thermal stimulation by moxibustion at different temperatures (38°C and 46°C). Results. The thermal stimulation by moxibustion at 2 temperatures may increase HR, MAP, LVSP, and +dp/dtmax and reduce t-dp/dtmax in brachycardia rats; the 46°C moxibustion group shows greater regulating effects on cardiac function in rats than that in the 38°C moxibustion group (P < 0.05). The thermal stimulation by moxibustion at 2 temperatures may promote degranulation of mast cells in the local site of moxibustion at the Ximen Acupoint; the degranulation rate in the 46°C moxibustion group is higher than that in the 38°C moxibustion group (P < 0.05). Conclusion. There is a certain association between the effect on the target organ and the effect in the local site of moxibustion. The moxibustion effect possibly resulted from local mast cells degranulation and different thermoreceptors activated by the thermal stimulation at different temperatures.
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Wang et al. (2013) studied brachycardia. Thermal stimulation by moxibustion at 46°C vs. Thermal stimulation by moxibustion at 38°C was evaluated on cardiac function and mast cell degranulation (p=< 0.05). Thermal stimulation by moxibustion at 46°C showed greater regulating effects on cardiac function and higher mast cell degranulation rates in brachycardia rats compared to 38°C (P < 0.05).
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