Atrial fibrillation: Improvement in identification and stroke preventive therapy —Data from the UK Clinical Practice Research Datalink, 2000–2012
Key result
Male sex is linked to higher first-year anticoagulation rates in new AF, 54% vs 45%.
- P<0.0001
- n=55,847
Why the study?
Identification and treatment for stroke prevention in atrial fibrillation have improved, but many patients remain suboptimally treated and sex disparities have existed.
Population
55,847 patients with atrial fibrillation first diagnosed between 2000 and 2012 in the UK CPRD
Comparison
Anticoagulation initiation rates in men versus women with atrial fibrillation
Design
Observational time trend analysis
Follow-up
1 year following diagnosis
Authors
Discussion
Loading...
Member takes
Implication
Rising AF incidence may warrant enhanced primary care vigilance; leaves open drivers of the trend and prevention implications.
Study Design
Type
Observational (n=55,847)
Multicenter
Yes
Structured PICO
P
Population
55,847 patients with newly diagnosed atrial fibrillation between 2000 and 2012 in the UK Clinical Practice Research Datalink.
O
Outcome
Incidence of atrial fibrillation and initiation of anticoagulation therapy in the first year following diagnosis
Main Result
Absolute Event Rate: 54% vs 45%
p-value: p=<0.0001
Between 2000 and 2012 in the UK, both the diagnosis of atrial fibrillation and the initiation of stroke preventive anticoagulation therapy increased, with the treatment gap between men and women narrowing.
Cite This Study
Scowcroft et al. (2013) conducted an observational in Atrial fibrillation (n=55,847). Male sex vs. Female sex was evaluated on Initiation of anticoagulation therapy in the first year following diagnosis (p=<0.0001). Male patients with newly diagnosed atrial fibrillation were more likely to be initiated on anticoagulation therapy in the first year than female patients (54% vs 45%, P<0.0001).