Key result
Deep neural network accurately synthesizes morphologically equivalent ECG, EMG, and respiration signals.
Why the study?
Modeling physiological signals is complex for understanding and synthesizing biomedical signals, motivating development of deep neural network models for this purpose.
A deep neural network using GRUs can successfully learn and synthesize biosignals like ECG and respiration with morphological equivalence to original signals.
Answers are grounded in this paper and cite their sources.
May augment biosignal datasets for research; leaves open clinical validation and utility.
BACKGROUND: Modeling physiological signals is a complex task both for understanding and synthesize biomedical signals. We propose a deep neural network model that learns and synthesizes biosignals, validated by the morphological equivalence of the original ones. This research could lead the creation of novel algorithms for signal reconstruction in heavily noisy data and source detection in biomedical engineering field. METHOD: The present work explores the gated recurrent units (GRU) employed in the training of respiration (RESP), electromyograms (EMG) and electrocardiograms (ECG). Each signal is pre-processed, segmented and quantized in a specific number of classes, corresponding to the amplitude of each sample and fed to the model, which is composed by an embedded matrix, three GRU blocks and a softmax function. This network is trained by adjusting its internal parameters, acquiring the representation of the abstract notion of the next value based on the previous ones. The simulated signal was generated by forecasting a random value and re-feeding itself. RESULTS AND CONCLUSIONS: The resulting generated signals are similar with the morphological expression of the originals. During the learning process, after a set of iterations, the model starts to grasp the basic morphological characteristics of the signal and later their cyclic characteristics. After training, these models' prediction are closer to the signals that trained them, specially the RESP and ECG. This synthesis mechanism has shown relevant results that inspire the use to characterize signals from other physiological sources.
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Belo et al. (2017) studied Healthy (n=34). Deep Neural Network (GRU) model vs. Original biosignals was evaluated on Morphological equivalence (Mean squared error). A deep neural network model using gated recurrent units successfully learned and synthesized respiration, electromyogram, and electrocardiogram signals with morphological equivalence to the original signals.
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