Key result
The presence of five or more unfavourable ACE and eNOS genotypes was associated with a 61.9-fold increased risk of Henoch-Schönlein purpura nephritis compared to having two or fewer unfavourable genotypes.
Why the study?
Further studies are required to prove the relationship between Henoch-Schönlein purpura nephritis and ACE and eNOS single nucleotide polymorphisms.
Are ACE and eNOS single nucleotide polymorphisms associated with susceptibility to Henoch-Schönlein purpura nephritis?
Case-Control (n=297)
No
Are ACE and eNOS single nucleotide polymorphisms associated with susceptibility to Henoch-Schönlein purpura nephritis?
Odds Ratio: 61.923 (95% CI 7.955–482.022)
p-value: p=<0.001
Specific single nucleotide polymorphisms in the ACE and eNOS genes are associated with increased susceptibility to Henoch-Schönlein purpura nephritis.
Previous studies have shown that insertion/deletion polymorphisms in the angiotensin-converting enzyme (ACE) gene and the endothelial nitric oxide synthase (eNOS) gene are associated with Henoch-Schönlein purpura nephritis (HSPN). However, further studies are required to prove the relationship between HSPN and ACE and eNOS single nucleotide polymorphisms (SNPs). We studied six ACE SNPs and two eNOS SNPs by genotyping HSPN patients. Statistical analyses indicate that four ACE SNPs and two eNOS SNPs are associated with HSPN susceptibility. A cumulative effect analysis suggested that an increased number of unfavourable genotypes may lead to an increased risk of HSPN. By comparing alleles, genotypes and haplotypes that are associated with lupus nephritis (LN) and HSPN, we found genetic heterogeneity between HSPN and LN.
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Di et al. (2012) conducted a case-control in Henoch-Schönlein purpura nephritis (n=297). 5 or more unfavourable ACE and eNOS genotypes vs. 2 or fewer unfavourable genotypes was evaluated on HSPN susceptibility (cumulative effect of unfavourable genotypes) (OR 61.923, 95% CI 7.955-482.022, p=<0.001). The presence of five or more unfavourable ACE and eNOS genotypes was associated with a 61.9-fold increased risk of Henoch-Schönlein purpura nephritis compared to having two or fewer unfavourable genotypes.
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